High Pressure Cryo-Cooler for X-Ray Crystallography (HPC-201)
04/03/2013 - 11/30/-0001
Lansing, NY, April 3, 2013 - ADC announced today it has signed a licensing agreement with The Cornell Center for Technology Enterprise & Commercialization (CCTEC) for commercialization of a High Pressure Cryo-Cooler for preparing protein crystals. This device is based on a process developed by Cornell University scientists Prof. Sol M. Gruner and Dr. Chae Un Kim. This exciting new technology enables the simultaneous capture of both amplitude and phase information from a single anomalous diffraction (SAD) of a cryocooled protein crystal, thereby providing sufficient data to solve the crystal structure of a protein with a previously unknown structure. Flash-freezing at atmospheric pressure requires the use of cryoprotectants. Finding the right cyroprotectant for each sample type can be a long, trial-and-error process. The High Pressure Cryo-Cooler eliminates the need to use cryoprotectants and produces superior results. The scatter images below of a glucose isomerase crystal prepared at atmospheric pressure (left) and under high pressure (right,) demonstrate the benefits of high-pressure cryocooling.
The Cornell University is an American private Ivy League research university located in Ithaca, New York, United States. Cornell, a research university, is ranked fourth in the world in producing the largest number of graduates who go on to pursue PhDs in engineering or the natural sciences at American institutions, as well as fifth in the world in producing graduates who pursue PhDs at American institutions in any field. Research is a central element of the university's mission; in 2009 Cornell spent $671 million on science and engineering research and development, the 16th highest in the United States.
About the company: ADC has over 17 years of experience and extensive capability in the machining and manufacturing of complex systems for the scientific community. We focus mainly on synchrotrons and neutron sources. We have an in house physicist and engineers for such things as magnet modeling for undulators, optics for beam lines, FEA and thermal analysis, as well as other disciplines. We have the facilities and equipment for UHV applications such as a class-50 clean room, leak checkers, RGAs, vacuum pumps, and UHV component cleaning and bagging facilities, as well as a highly trained staff.